An Efficient New Procedure for the One-Pot Conversion of Aldehydes into the Corresponding Nitriles
08 May 2007 (online)
A new and efficient procedure for the one-pot conversion of various aldehydes into the corresponding nitriles under mild reaction conditions has been developed. The ethyl dichlorophosphate/DBU-mediated dehydration of aldoxime intermediates was utilized as a key operation to effect the transformation.
aldehydes - nitriles - ethyl dichlorophosphate - DBU - dehydration