Synlett 2007(8): 1317-1319  
DOI: 10.1055/s-2007-980338
LETTER
© Georg Thieme Verlag Stuttgart · New York

An Efficient New Procedure for the One-Pot Conversion of Aldehydes into the Corresponding Nitriles

Jia-Liang Zhu*a, Fa-Yen Leea, Jen-Dar Wub, Chun-Wei Kuob, Kak-Shan Shia*b
a Department of Chemistry, National Dong-Hwa University, Hualien 974, Taiwan, R.O.C.
Fax: +886(38)633570; e-Mail: jlzhu@mail.ndhu.edu.tw;
b Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli 350, Taiwan, R.O.C.
Fax: +886(37)586456; e-Mail: ksshia@nhri.org.tw;
Further Information

Publication History

Received 30 January 2007
Publication Date:
08 May 2007 (online)

Abstract

A new and efficient procedure for the one-pot conversion of various aldehydes into the corresponding nitriles under mild reaction conditions has been developed. The ethyl dichlorophosphate/DBU-mediated dehydration of aldoxime intermediates was utilized as a key operation to effect the transformation.