Synlett 2007(7): 1166-1168  
DOI: 10.1055/s-2007-977428
CLUSTER
© Georg Thieme Verlag Stuttgart · New York

Highly Diastereoselective Electrophilic Fluorination of Cyclic syn-β-
Hydroxysilanes

Sophie Pursera, Christopher Wilsona, Peter R. Mooreb, Véronique Gouverneur*a
a The Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3IA, UK
Fax: +44(1865)275644; e-Mail: veronique.gouverneur@chem.ox.ac.uk;
b AstraZeneca Discovery Chemistry, Alderley Park, Macclesfield, Cheshire SK10 4TF, UK
Further Information

Publication History

Received 17 November 2006
Publication Date:
13 April 2007 (online)

Abstract

A synthesis of enantioenriched fluorinated carbocycles has been developed combining a sequential enantioselective silyl­allylboration-ring-closing metathesis with a highly diastereoselective electrophilic fluorination.