Zusammenfassung
Die Phototherapie ist eine altbewährte dermatologische Behandlungsmethode. Schon in
der Antike wurden bestimmte Hauterkrankungen mit Sonnenlichtexposition therapiert.
Mit Beginn des 20. Jahrhunderts entwickelte sich die moderne UV-Therapie. Zunächst
konzentrierte man sich auf die Behandlung der Psoriasis, wofür Breitspektrum-UVB eingesetzt
wurde. Seit diesen Anfängen hat sich das Indikationsspektrum der UVB Phototherapie
über die vielen Jahrzehnte der klinischen Anwendung hin deutlich erweitert. In dieser
Arbeit werden die in der klinischen Praxis am häufigsten vorkommenden Erkrankungen
besprochen, für die eine solche UVB Behandlung infrage kommt.
Summary
Phototherapy is a very old and an established dermatological treatment option. Already
the ancient egyptians used the therapeutic effects of natural sunlight to treat skin
diseases. The beginning of the 20th century then marked the start of modern phototherapy.
One focus was the treatment of psoriasis, for which broadband UVB was initially used.
Since these beginnings the indication spectrum has expanded over the many years of
clinical practice. Nowadays there are quite a few dermatological and medical conditions,
in which a UVB-phototherapy is the first line treatment option. This review discusses
the most common clinical indications for UVB-phototherapy.
Schlüsselwörter
UVB - Phototherapie - dermatologische Indikation - internistische Indikation
Key words
UVB - phototherapy - dermatological conditions - medical conditions
Literatur
- 1
Berneburg M, Brod C, Benedix F, Rocken M.
New and established indications for phototherapy with narrowband UVB.
J Dtsch Dermatol Ges.
2005;
3
874-882
- 2
Bilsland D, George S A, Gibbs N K, Aitchison T, Johnson B E, Ferguson J.
A comparison of narrow band phototherapy (TL-01) and photochemotherapy (PUVA) in the
management of polymorphic light eruption.
Br J Dermatol.
1993;
129
708-712
- 3
Clark C, Dawe R S, Evans A T, Lowe G, Ferguson J.
Narrowband TL-01 phototherapy for patch-stage mycosis fungoides.
Arch Dermatol.
2000;
136
748-752
- 4
Feldman S R, Fleischer A B, Reboussin D M. et al .
The economic impact of psoriasis increases with psoriasis severity.
J Am Acad Dermatol.
1997;
37
564-569
- 5
Gambichler T, Breuckmann F, Boms S, Altmeyer P, Kreuter A.
Narrowband UVB phototherapy in skin conditions beyond psoriasis.
J Am Acad Dermatol.
2005;
52
660-670
- 6
Hofer A, Cerroni L, Kerl H, Wolf P.
Narrowband (311-nm) UV-B therapy for small plaque parapsoriasis and early-stage mycosis
fungoides.
Arch Dermatol.
1999;
135
1377-1380
- 7
Honigsmann H.
Phototherapy for psoriasis.
Clin Exp Dermatol.
2001;
26
343-350
- 8
Hsu M M, Yang C C.
Uraemic pruritus responsive to broadband ultraviolet (UV) B therapy does not readily
respond to narrowband UVB therapy.
Br J Dermatol.
2003;
149
888-889
- 9
Juhlin L.
Improvement of vitiligo after oral treatment with vitamin B12 and folic acid and the
importance of sun exposure.
Acta Derm Venerol.
1997;
77
460-462
- 10
Lee E, Koo J, Berger T.
UVB phototherapy and skin cancer risk: a review of the literature.
Int J Dermatol.
2005;
44
355-360
- 11
Legat F J, Hofer A, Brabek E, Quehenberger F, Kerl H, Wolf P.
Narrowband UV-B vs medium-dose UV-A1 phototherapy in chronic atopic dermatitis.
Arch Dermatol.
2003;
139
223-224
- 12 Lehmann P. Photodermatosen. Heidelberg: Springer In: Braun-Falco O, Plewig G, Wolff
HH, Burgdorf W, Landthaler M, editors. Dermatologie und Venerologie 2006: 545-569
- 13
Miller D W, Feldman S R.
Cost-effectiveness of moderate-to-severe psoriasis treatment.
Expert Opin Pharmacother.
2006;
7
157-167
- 14
Njoo M D, Bos J D, Westerhof W.
Treatment of generalized vitiligo in children with narrow-band (TL-01) UVB radiation
therapy.
J Am Acad Dermatol.
2000;
42
245-253
- 15
Parrish J A, Jaenicke K F.
Action spectrum for phototherapy of psoriasis.
J Invest Dermatol.
1981;
76
359-362
- 16
Samson Yashar S, Gielczyk R, Scherschun L, Lim H W.
Narrow-band ultraviolet B treatment for vitiligo, pruritus, and inflammatory dermatoses.
Photodermatol Photoimmunol Photomed.
2003;
19
164-168
- 17
Tjioe M, Gerritsen M J, Juhlin L, van de Kerkhof P C.
Treatment of vitiligo vulgaris with narrow band UVB (311 nm) for one year and the
effect of addition of folic acid and vitamin B12.
Acta Derm Venereol.
2002;
82
369-372
- 18
Westerhof W, Nieuweboer-Krobotova L.
Treatment of vitiligo with UV-B radiation vs topical psoralen plus UV-A.
Arch Dermatol.
1997;
133
1525-1528
Professor Dr. med. Karin Scharffetter-Kochanek
Universitätsklinik und Poliklinik für Dermatologie und Allergologie
Maienweg 12
89081 Ulm
Telefon: 0731/50021801
Fax: 0731/50021870
eMail: karin.scharffetter-kochanek@uniklinik-ulm.de
