Synlett 2007(5): 0725-0728  
DOI: 10.1055/s-2007-970764
LETTER
© Georg Thieme Verlag Stuttgart · New York

A C 2-Symmetric Metallocene-Pyrrolidinopyridine Nucleophilic Catalyst for Asymmetric Synthesis

Huy V. Nguyen, Majid Motevalli, Christopher J. Richards*
School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
Fax: +44(20)78827794; e-Mail: c.j.richards@qmul.ac.uk;
Further Information

Publication History

Received 12 January 2007
Publication Date:
08 March 2007 (online)

Abstract

A C 2-symmetric nucleophilic catalyst, (R,R)-3,5-diferrocenyl-4-(2′,5′-dimethylpyrrolidino)pyridine, was synthesised in three steps from commercially available (S,S)-hexane-2,5-diol. ­Application to the kinetic resolution of secondary alcohols (0.5 mol% loading) resulted in selectivity factors (s) of up to 6.