A C 2-Symmetric Metallocene-Pyrrolidinopyridine Nucleophilic Catalyst for Asymmetric Synthesis
08 March 2007 (online)
A C 2-symmetric nucleophilic catalyst, (R,R)-3,5-diferrocenyl-4-(2′,5′-dimethylpyrrolidino)pyridine, was synthesised in three steps from commercially available (S,S)-hexane-2,5-diol. Application to the kinetic resolution of secondary alcohols (0.5 mol% loading) resulted in selectivity factors (s) of up to 6.
alcohols - asymmetric catalysis - kinetic resolution - metallocenes - nucleophiles