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Dtsch Med Wochenschr 2007; 132(8): 383-390
DOI: 10.1055/s-2007-970345
CME-Beitrag | Review article
Hämatologie
© Georg Thieme Verlag KG Stuttgart · New York

Idiopathische thrombozytopenische Purpura (ITP)

Idiopathic Thrombocytopenic PurpuraR. Schroers1 , U. Dührsen1
  • 1Abteilung Hämatologie, Universitätsklinikum Essen
Further Information

Publication History

eingereicht: 13.11.2006

akzeptiert: 12.2.2007

Publication Date:
14 February 2007 (online)

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Schlüsselwörter

Idiopathische thrombozytopenische Purpura - Morbus Werlhof - Thrombozytopenie

Schlüsselwörter

idiopathic thrombocytopenic purpura - Werlhof disease - thrombocytopenia

Literatur

  • 1 Cines D B, Blanchette V S. Immune thrombocytopenic purpura.  N Engl J Med. 2002;  346 995-1008
    Google Scholar
  • 2 Neylon A J, Saunders P W, Howard M R, Proctor S J, Taylor P R. Clinically significant newly presenting autoimmune thrombocytopenic purpura in adults: a prospective study of a population-based cohort of 245 patients.  Br J Haematol. 2003;  122 966-974
    Google Scholar
  • 3 Andersson P O, Wadenvik H. Chronic idiopathic thrombocytopenic purpura (ITP): molecular mechanisms and implications for therapy.  Expert Rev Mol Med. 2004;  6 1-17
    Google Scholar
  • 4 Kuwana M, Ikeda Y. The role of autoreactive T-cells in the pathogenesis of idiopathic thrombocytopenic purpura.  Int J Hematol. 2005;  81 106-112
    Google Scholar
  • 5 Cooper N, Bussel J. The pathogenesis of immune thrombocytopaenic purpura.  Br J Haematol. 2006;  133 364-374
    Google Scholar
  • 6 Doan C A, Bouroncle B A, Wiseman B K. Idiopathic and secanodary thrombocytopenic purpura: clinical study and evaluation of 382 cases over a period of 28 years.  Ann Intern Med. 1960;  53 861-876
    Google Scholar
  • 7 Cines D B, McMillan R. Management of adult idiopathic thrombocytopenic purpura.  Annu Rev Med. 2005;  56 425-442
    Google Scholar
  • 8 Bussel J. Treatment of immune thrombocytopenic purpura in adults.  Semin Hematol. 2006;  43 (Suppl 5) S3-10
    Google Scholar
  • 9 George J N. Clinical practice. Thrombotic thrombocytopenic purpura.  N Engl J Med. 2006;  354 1927-1935
    Google Scholar
  • 10 Drachman J G. Inherited thrombocytopenia: when a low platelet count does not mean ITP.  Blood. 2004;  103 390-398
    Google Scholar
  • 11 Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy.  Br J Haematol. 2003;  120 574-596
    Google Scholar
  • 12 Heilmann L. Hemostasis disorders in obstetrics and gynecology.  Hamostaseologie. 2004;  24 252-260
    Google Scholar
  • 13 George J N, Woolf S H, Raskob G E. Idiopathic thrombocytopenic purpura: a guideline for diagnosis and management of children and adults: American Society of Hematology.  Ann Med. 1998;  30 38-44
    Google Scholar
  • 14 Borst F, Keuning J J, van Hulsteijn H, Sinnige H, Vreugdenhil G. High-dose dexamethasone as a first- and second-line treatment of idiopathic thrombocytopenic purpura in adults.  Ann Hematol. 2004;  83 764-768
    Google Scholar
  • 15 Culic S. Recombinant factor VIIa for refractive haemorrhage in autoimmune idiopathic thrombocytopenic purpura.  Br J Haematol. 2003;  120 909-910
    Google Scholar
  • 16 Godeau B, Chevret S, Varet B. et al . Intravenous immunoglobulin or high-dose methylprednisolone, with or without oral prednisone, for adults with untreated severe autoimmune thrombocytopenic purpura: a randomised, multicentre trial.  Lancet. 2002;  359 23-29
    Google Scholar
  • 17 Bierling P, Godeau B. Intravenous immunoglobulin and autoimmune thrombocytopenic purpura: 22 years on.  Vox Sang. 2004;  86 8-14
    Google Scholar
  • 18 Kojouri K, Vesely S K, Terrell D R, George J N. Splenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complications.  Blood. 2004;  104 2623-2634
    Google Scholar
  • 19 Penalver F J, Jimenez-Yuste V, Almagro M. et al . Rituximab in the management of chronic immune thrombocytopenic purpura: an effective and safe therapeutic alternative in refractory patients.  Ann Hematol. 2006;  85 400-406
    Google Scholar
  • 20 Vesely S K, Perdue J J, Rizvi M A, Terrell D R, George J N. Management of adult patients with persistent idiopathic thrombocytopenic purpura following splenectomy: a systematic review.  Ann Intern Med. 2004;  140 112-120
    Google Scholar
  • 21 Cines D B, Bussel J B. How I treat idiopathic thrombocytopenic purpura (ITP).  Blood. 2005;  106 2244-2251
    Google Scholar
  • 22 Kappers-Klunne M C, van’t Veer M B. Cyclosporin A for the treatment of patients with chronic idiopathic thrombocytopenic purpura refractory to corticosteroids or splenectomy.  Br J Haematol. 2001;  114 121-125
    Google Scholar
  • 23 Provan D, Moss A J, Newland A C, Bussel J B. Efficacy of mycophenolate mofetil as single-agent therapy for refractory immune thrombocytopenic purpura.  Am J Hematol. 2006;  81 19-25
    Google Scholar
  • 24 Huhn R D, Fogarty P F, Nakamura R. et al . High-dose cyclophosphamide with autologous lymphocyte-depleted peripheral blood stem cell (PBSC) support for treatment of refractory chronic autoimmune thrombocytopenia.  Blood. 2003;  101 71-77
    Google Scholar
  • 25 Bussel J B, Kuter D J, George J N. et al . AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP.  N Engl J Med. 2006;  355 1672-1681
    Google Scholar
  • 26 Vianelli N, Valdre L, Fiacchini M. et al . Long-term follow-up of idiopathic thrombocytopenic purpura in 310 patients.  Haematologica. 2001;  86 504-509
    Google Scholar
  • 27 Cohen Y C, Djulbegovic B, Shamai-Lubovitz O, Mozes B. The bleeding risk and natural history of idiopathic thrombocytopenic purpura in patients with persistent low platelet counts.  Arch Intern Med. 2000;  160 1630-1638
    Google Scholar

Priv.-Doz. Dr. med. Roland Schroers

Universitätsklinikum Essen, Zentrum für Innere Medizin, Klinik für Hämatologie

Hufelandstraße 55

45122 Essen

Phone: 0201/7232417

Fax: 0201/7235928

Email: R.Schroers@web.de

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