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Synfacts 2007(4): 0355-0355  
DOI: 10.1055/s-2007-968287
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Moenomycin A

Contributor(s): Philip Kocienski
J. G. Taylor, X. Li, M. Oberthür, W. Zhu, D. E. Kahne*
Harvard University, Cambridge and Harvard Medical School, Boston, USA
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Publikationsdatum:
23. März 2007 (online)

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Significance

Moenomycin A inhibits bacterial cell wall biosynthesis by binding to transglycosylases that mediate the formation of the carbohydrate chains of peptidoglycan. The four glycosylation reactions involving sterically hindered or electronically deactivated donors or acceptors were accomplished using sulfoxide glycosylation.