Synthesis 2007(8): 1165-1168  
DOI: 10.1055/s-2007-965984
PAPER
© Georg Thieme Verlag Stuttgart · New York

An Efficient Method for the α-Acetoxylation of Ketones

Jinmei Sheng, Xiaolong Li, Mingfang Tang, Botao Gao, Guosheng Huang*
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
Fax: +86(931)8912582; e-Mail: hgs2368@163.com;
Further Information

Publication History

Received 29 November 2006
Publication Date:
12 March 2007 (online)

Abstract

α-Acetoxylation of ketones catalyzed by iodobenzene using 30% aqueous hydrogen peroxide and acetic anhydride as the oxidant is an effective and economical method for the preparation of α-acetoxy ketones. The reaction gave the products in good yields without the addition of acetic acid and water.

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9

If the mixture was stirred at 40 °C for 4 h, it only needed to be cooled to r.t.