Synthesis 2007(8): 1230-1234
DOI: 10.1055/s-2007-965974
DOI: 10.1055/s-2007-965974
PAPER
© Georg Thieme Verlag Stuttgart · New YorkSolvent-Free Synthesis of Racemic α-Aminonitriles
Further Information
Received
2 February 2007
Publication Date:
28 February 2007 (online)
Publication History
Publication Date:
28 February 2007 (online)

Abstract
A very simple one-step, environmentally friendly procedure for the synthesis of α-aminonitriles from aldehydes and ketones, using trimethylsilyl cyanide in the absence of solvent, is reported. The active catalyst of this three-component (Strecker) reaction was the amine employed in the transformation. In general, aldehydes react more rapidly than ketones and give almost quantitative yields of the corresponding α-aminonitriles in less than fifteen minutes. However, only cyclic ketones afford the corresponding α-aminonitriles in excellent chemical yields under these conditions.
Key words
addition reactions - Strecker synthesis - catalysis - aminonitriles - green chemistry - solvent-free
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