Abstract
Background: We investigated the effect of lazaroid U74389G, a potent inhibitor of lipid peroxidation,
on ischemia-reperfusion injury at three different doses in the rat orthotopic left
lung transplantation model. Methods: Four groups of reperfused lungs were studied. In group I (control) donor lungs were
transplanted after 12 hours of preservation in University of Wisconsin (UW) Solution
at 4°C. In groups II, III, and IV, lazaroid was used as an additive to UW Solution
at concentrations of 30 μmol/L, 50 μoml/L, and 100 μmol/L respectively, and was also
administered intravenously to the recipients 30 minutes before reperfusion after 12
hours of storage in the UW solution at 4 C. Results: After 1 hour of reperfusion, gas exchange function (p < 0.01), tissue lipid peroxide
levels (p< 0.05) and histologic damage in reperfused lung allografts (p< 0.05) were
significantly improved in lazaroidtreated group IV compared with control group I.
Conclusions: These findings suggest that lazaroid U74389G ameliorates ischemia-reperfusion injury
in rat lung transplants by inhibiting lipid peroxidation.
Key words
Lazaroid U74389G - Ischemia reperfusion injury - Lipid peroxidation - Lung transplantation
