Synlett 2007(20): 3155-3159  
DOI: 10.1055/s-2007-1000821
© Georg Thieme Verlag Stuttgart · New York

Application of a Samarium(II)-Mediated Spirocyclisation in an Asymmetric Approach to the Cyclopentanol Motif of Stolonidiol

Lisa A. Sloana, Thomas M. Bakera, Simon J. F. Macdonaldb, David J. Procter*a
a The School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK
b GlaxoSmithKline R&D Ltd, Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK
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Further Information

Publication History

Received 21 August 2007
Publication Date:
03 December 2007 (eFirst)


An asymmetric approach to the cyclopentanol motif of the biologically active, marine natural product stolonidiol has been developed. The approach involves the asymmetric synthesis of chiral γ,δ-unsaturated ketones and their spirocyclisation using SmI2.