Synlett 2007(20): 3155-3159
DOI: 10.1055/s-2007-1000821
DOI: 10.1055/s-2007-1000821
LETTER
© Georg Thieme Verlag Stuttgart · New YorkApplication of a Samarium(II)-Mediated Spirocyclisation in an Asymmetric Approach to the Cyclopentanol Motif of Stolonidiol
Further Information
Received
21 August 2007
Publication Date:
03 December 2007 (eFirst)
Publication History
Publication Date:
03 December 2007 (eFirst)

Abstract
An asymmetric approach to the cyclopentanol motif of the biologically active, marine natural product stolonidiol has been developed. The approach involves the asymmetric synthesis of chiral γ,δ-unsaturated ketones and their spirocyclisation using SmI2.
Key words
samarium - radical reactions - asymmetric synthesis - natural products - spiro compounds