Niobium Fluoride (NbF₅): A Highly Efficient Catalyst for Solvent-Free Cyanosilylation of Aldehydes

Abstract

An efficient method for the addition of trimethylsilylcyanide (TMSCN) to aldehydes using dispersed NbF₅ as the catalyst is described. Cyano transfer from TMSCN to aldehydes occurs within 10 minutes at room temperature in the presence of 0.5 mol% of NbF₅ under solvent-free conditions giving cyanohydrins in excellent yields of over 95%. These conditions are extremely mild, simple and tolerate various functional groups.

aldehydes - catalysis - green chemistry - cyanohydrins - solvent-free

References

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Dr. G. Rajagopal is a Brain Pool Scientist from the Department of Chemistry, BSA Crescent Engineering College, Chennai 600 048, India. He was assisted by a grant from the Korean Federation of Science and Technology Societies and Korea Science and Engineering Foundation.

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