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© Georg Thieme Verlag Stuttgart · New York
Dual Inhibitory Activities of Tannins from Hamamelis virginiana and Related Polyphenols on 5-Lipoxygenase and Lyso-PAF: Acetyl-CoA Acetyltransferase11 Presented in parts during the meeting of the Society of Medicinal Plant Research, Halle/Saale, Germany, Sept. 1995. Part of the projected thesis of C Hartisch
04 January 2007 (online)
In the present study, the effects of tannins obtained from various plant sources on the activity of 5-LOX and AT were examined. With IC50 values ranging from 1.0 to 18.7 µM, hamamelitannin and the galloylated proanthocyanidins isolated from Hamamelis virginiana L. were found to be most potent inhibitors of 5-LOX. Unlike the 5-LOX study, hamamelitannin proved to be ineffective in the AT assay. Potent candidates are represented by the group of B-type proanthocyanidins. Structure-activity relationships regarding the in vitro inhibitory potency of the polyphenols in the biological assays are discussed.
Hamamelis virginiana - Hamamelidaceae - hamamelitannin - proanthocyanidins - 5-lipoxygenase - lyso-PAF: acetyl-CoA acetyltransferase