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Planta Med 1997; 63(2): 106-110
DOI: 10.1055/s-2006-957623
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Pharmacology and Molecular Biology
© Georg Thieme Verlag Stuttgart · New York

Dual Inhibitory Activities of Tannins from Hamamelis virginiana and Related Polyphenols on 5-Lipoxygenase and Lyso-PAF: Acetyl-CoA Acetyltransferase1

Claudia Hartisch2 , Herbert Kolodziej2 , Fritz von Bruchhausen3
  • 2Institut für Pharmazie II, Pharmazeutische Biologie, Freie Universität Berlin, Berlin, Germany
  • 3Institut für Pharmakologie, Universitätsklinikum Rudolf Virchow, Berlin, Germany
1 Presented in parts during the meeting of the Society of Medicinal Plant Research, Halle/Saale, Germany, Sept. 1995. Part of the projected thesis of C Hartisch
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Publication History

1996

1996

Publication Date:
04 January 2007 (online)

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Abstract

In the present study, the effects of tannins obtained from various plant sources on the activity of 5-LOX and AT were examined. With IC50 values ranging from 1.0 to 18.7 µM, hamamelitannin and the galloylated proanthocyanidins isolated from Hamamelis virginiana L. were found to be most potent inhibitors of 5-LOX. Unlike the 5-LOX study, hamamelitannin proved to be ineffective in the AT assay. Potent candidates are represented by the group of B-type proanthocyanidins. Structure-activity relationships regarding the in vitro inhibitory potency of the polyphenols in the biological assays are discussed.

key words

Hamamelis virginiana - Hamamelidaceae - hamamelitannin - proanthocyanidins - 5-lipoxygenase - lyso-PAF: acetyl-CoA acetyltransferase

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