Indium Tribromide: An Efficient Catalyst for the Silylation of Hydroxy Groups by the Activation of Hexamethyldisilazane [1]

Abstract

A variety of substrates containing hydroxy groups have been protected as their corresponding trimethylsilyl ethers using 1,1,1,3,3,3-hexamethyldisilazane in the presence of indium tribromide. The catalyst indium tribromide activates the 1,1,1,3,3,3-hexa­methyldisilazane and accelerates the reaction under mild reaction conditions at room temperature.

Keywords

indium tribromide - 1,1,1,3,3,3-hexamethyldisilazane - protection - hydroxy group - silylation

1

IICT Communication No: 050724.

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IICT Communication No: 050724.