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Synlett 2006(14): 2334-2338
DOI: 10.1055/s-2006-949648
DOI: 10.1055/s-2006-949648
CLUSTER
© Georg Thieme Verlag Stuttgart · New YorkA Focused Library of Tetrahydropyrimidinone Amides via a Tandem Biginelli-Ugi Multi-Component Process
Further Information
Received
30 May 2006
Publication Date:
24 August 2006 (online)
Publication History
Publication Date:
24 August 2006 (online)
Abstract
A second generation focused library of 30 tetrahydropyrimidinone amides was prepared. The design was based on the structure of an Hsp70 modulator. This small library demonstrates the utility of tandem multi-component reactions in structure-activity relationship studies of biological lead molecules. The tandem Biginelli-Ugi multi-component reaction facilitated the effective variation of four different substituents and allowed the synthesis of the library members in a sequence of only two one-pot reactions.
Key words
Biginelli reactions - Ugi reactions - cascades - Hsp70 - pyrimidinones
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