A Mitsunobu Diol Cyclisation to Chiral Morpholines and Dioxanes

Abstract

A diol cyclisation under Mitsunobu conditions is presented, which allows access to chiral substituted morpholines and dioxanes.

Mitsunobu reaction - heterocycles - asymmetric - morpholines - pharmaceuticals

References

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4 Chiral morpholine synthesis via tosylation, see: Myers AG. Lanman BA. Org. Lett.  2004,  6:  1045 

5 Hayes MA, Mills G, Swanson S, Walker AJ, and Wilkinson M. inventors; PCT Int. Appl. WO  2003082835.  ; Chem. Abstr. 2003, 139, 307774

6 For other routes, see: Wilkinson MC. Tetrahedron Lett.  2005,  46:  4773