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Synthesis 2006(14): 2301-2304  
DOI: 10.1055/s-2006-942442
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Carbon-11 Labeled Triphenylacetamides as Novel Potential PET Melanoma Cancer Imaging Agents

Mingzhang Gaoa, Deyuan Kongb, Abraham Clearfieldb, Kathy D. Millerc, George W. Sledgec, Qi-Huang Zheng*a
a Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Fax: +1(317)2789711; e-Mail: qzheng@iupui.edu;
b Department of Chemistry, Texas A&M University, College Station, TX 77843, USA
c Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
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Publikationsverlauf

Received 11 February 2006
Publikationsdatum:
28. Juni 2006 (online)

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Abstract

New carbon-11 labeled triphenylacetamides (TPAs), N-(4-[11C]methoxyphenyl)-2,2,2-triphenyl-acetamide ([11C]MTA) and 3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [11C]methyl ester ([11C]PAME), were designed and synthesized as potential positron emission tomography (PET) melanoma cancer imaging agents. The single crystal structure of the potent anti-melanoma agent, N-(4-methoxyphenyl)-2,2,2-triphenylacetamide (MTA) is reported.

Key words

triphenylacetamides - N-(4-[11C]methoxyphenyl)-2,2,2-tri­phenylacetamide - 3-phenyl-(R)-2-(2,2,2-triphenylacetyl­amino)propionic acid [11C]methyl ester - positron emission tomography - melanoma cancer - imaging agents