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Synthesis 2006(12): 1940-1942  
DOI: 10.1055/s-2006-942359
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

A Practical Regiospecific Synthesis of 9-Nitrocamptothecin

QingQuan Fua,b, Zhiyong Chen*a
a Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, N. 9, Section 4, Renmin South Road, Chengdu 610041, P. R. of China
Fax: +86(28)85229250; e-Mail: chenzy@cioc.ac.cn;
b Graduate School of Chinese Academy of Sciences, YuQuan Road, Beijing 10049, P. R. of China
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Publication History

Received 22 December 2005
Publication Date:
05 May 2006 (online)

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Abstract

9-Nitrocamptothecin has shown potent antitumor activity against many types of human cancers. A practical scale-up procedure for this compound is reported by selective reduction of corresponding sulfonate.

Key words

9-nitrocamptothecin - nitration - reduction of sulfonate