Synlett 2006(7): 1128-1129  
DOI: 10.1055/s-2006-939685
SPOTLIGHT
© Georg Thieme Verlag Stuttgart · New York

Grubbs’ Metathesis Catalyst - A Versatile Catalysts for Non-Metathetic Reactions

Anuradha Mukherjee*
Department of Organic Chemistry, Indian Association for the ­Cultivation of Science, Kolkata 700 032, India.
Fax: +91(332473)2805; e-Mail: anum76@rediffmail.com;
Further Information

Publication History

Publication Date:
24 April 2006 (online)

Introduction

Grubbs’ ruthenium-based catalysts (1 and 2) have demonstrated remarkable efficiency in olefin metathesis over the past ten years. [1] However, non-metathetic applications ­appeared very recently that deserve special attention and broaden the synthetic utility of Grubbs’ catalysts. [2] The complexes were shown to catalyze the Kharasch addition, the removal of allyl groups from amines, the atom-transfer radical polymerization, [3] the hydrogenation of olefins, the transfer hydrogenation of ketones, [4] the dehydro­genative oxidation of alcohols, the dehydrogenative condensation of alcohols, isomerization, hydrosilylation of alkynes, cycloaddition and the hydro-silylation of carbonyls. [5] The aim of this article is to give some examples of these advances, with special focus on practical concerns.

Catalyst 1 is prepared by treatment of phenyl diazo­methane with RuCl2(PPh3)3 complex, followed by replacement of PPh3 with PCy3. [6] The replacement of one PCy3 ligand by an imidazol-based N-heterocyclic carbene (NHC) from complex 1 affords catalyst 2 in quantitative yield. [7] Both catalysts are very stable to air and moisture.

    References and Notes

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