Stereoselective Synthesis of an Immunomodulator (+)-Conagenin Using ­Dirhodium(II)-Catalyzed C-H Amination and Chelation-Controlled ­Reductions as Key Steps

Abstract

Stereoselective synthesis of an immunomodulator (+)-conagenin from commercially available optically active methyl 3-hydroxy-2-methylpropanoate was achieved using dirhodium(II)-catalyzed C-H amination and chelation-controlled reductions as key steps.

conagenin - immunomodulator - dirhodium(II) - C-H amination - chelation control - reduction

References and Notes

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The stereochemistries of neither diastereomer were determined.