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Synfacts 2006(3): 0202-0202  
DOI: 10.1055/s-2006-931967
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Isoquinolines by Nickel-Catalyzed Heteroannulation

Contributor(s): Victor Snieckus, Robert Engqvist
R. P. Korivi, C.-H. Cheng*
National Tsing Hua University, Hsinchu, Taiwan
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Publikationsverlauf

Publikationsdatum:
21. Februar 2006 (online)

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Significance

A method for the synthesis of substituted isoquinolines from the reaction of tert-butyl imines of 2-halobenzaldehydes and alkynes under nickel catalysis is reported. The reactions proceed in good to excellent yields and with high regioselectivity for unsymmetrical alkynes. Two possible mechanistic pathways were proposed without experimental evidence.