Reinheckel Protocol Revisited: Synthesis of (E)-α,β-Unsaturated Sulfoxides

Abstract

A new synthetic approach to aryl and alkyl α,β-unsaturated sulfoxides is reported. The reaction has been optimized with respect to solvent, temperature, and ratio of reagents. The described procedure allows the synthesis of the title compounds in good yields (71-82%) starting from readily available reagents, in a cost-effective procedure.

Key words

sulfoxides - organometallic reagents - alk-1-enyl alanes - aluminum - Reinheckel reaction

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