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Synthesis 2005(18): 3079-3084
DOI: 10.1055/s-2005-918423
DOI: 10.1055/s-2005-918423
PAPER
© Georg Thieme Verlag Stuttgart · New YorkFormal Enantioselective Synthesis of (-)-Carbovir and (-)-Abacavir: An Application of the Rhodium(I)-Catalysed Tandem Hydrosilylation-Intramolecular Aldol Reaction
Further Information
Received
1 June 2005
Publication Date:
12 October 2005 (online)
Publication History
Publication Date:
12 October 2005 (online)
Abstract
An efficient synthesis of the highly potent anti-HIV carbocyclic nucleosides (-)-carbovir and (-)-abacavir has been accomplished from d-(-)-ribose using a rhodium(I)-catalysed tandem hydrosilylation-intramolecular aldol strategy to access a key intermediate.
Key words
asymmetric synthesis - carbocyclic nucleosides - aldol reaction - hydrosilylation - rhodium
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