Synlett 2005(15): 2321-2324  
DOI: 10.1055/s-2005-872672
© Georg Thieme Verlag Stuttgart · New York

An Efficient and General One-Pot Method for the Synthesis of Chiral Bis(oxazoline) and Pyridine Bis(oxazoline) Ligands

A. Cornejob, J. M. Frailea, J. I. García*a, M. J. Gilb, V. Martínez-Merinob, J. A. Mayorala, E. Pires*a, I. Villalbaa
a Departamento de Química Orgánica, Facultad de Ciencias, Instituto de Ciencia de Materiales de Aragón and Instituto Universitario de Catálisis Homogénea, Universidad de Zaragoza-CSIC, 50009 Zaragoza, Spain
Fax: +34(976)762077; e-Mail:;
b Departamento de Química Aplicada, Universidad Pública de Navarra, 31006 Pamplona, Spain
Further Information

Publication History

Received 19 May 2005
Publication Date:
07 September 2005 (online)


An expeditious method for the synthesis of chiral box and pybox ligands is reported. The approach is based on a one-pot condensation reaction of chiral β-amino alcohols with a dinitrile ­using stoichiometric or catalytic amounts of zinc triflate. Yields greater than 90% are obtained in many cases without the need for further purification of the product.