An Efficient and General One-Pot Method for the Synthesis of Chiral Bis(oxazoline) and Pyridine Bis(oxazoline) Ligands
07 September 2005 (online)
An expeditious method for the synthesis of chiral box and pybox ligands is reported. The approach is based on a one-pot condensation reaction of chiral β-amino alcohols with a dinitrile using stoichiometric or catalytic amounts of zinc triflate. Yields greater than 90% are obtained in many cases without the need for further purification of the product.
bis(oxazolines) - pybox - synthesis - zinc triflate - toluene - chiral ligands