Acid-Mediated Amine Exchange of N,N-Dimethylformamidines: Preparation of Electron-Rich Formamidines

Abstract

The effect of acid in the amine exchange of N,N-dimethylformamidines has been revisited, allowing the preparation of highly electron-rich compounds that are difficult to obtain under standard conditions. The use of propargylamine as nucleophile led to the formation of substituted imidazoles.

Key words

formamidine - acid - amine exchange - imidazole

References

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7

See ref. 6d and ref. 3-6 cited therein.