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Synlett 2005(14): 2214-2218
DOI: 10.1055/s-2005-872249
DOI: 10.1055/s-2005-872249
LETTER
© Georg Thieme Verlag Stuttgart · New York
Acid-Mediated Amine Exchange of N,N-Dimethylformamidines: Preparation of Electron-Rich Formamidines
Further Information
Received
24 March 2005
Publication Date:
26 July 2005 (online)
Publication History
Publication Date:
26 July 2005 (online)
Abstract
The effect of acid in the amine exchange of N,N-dimethylformamidines has been revisited, allowing the preparation of highly electron-rich compounds that are difficult to obtain under standard conditions. The use of propargylamine as nucleophile led to the formation of substituted imidazoles.
Key words
formamidine - acid - amine exchange - imidazole
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