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Synlett 2005(14): 2209-2213
DOI: 10.1055/s-2005-872248
DOI: 10.1055/s-2005-872248
LETTER
© Georg Thieme Verlag Stuttgart · New York
Rapid Synthesis of Aryl Azides from Aryl Halides under Mild Conditions
Further Information
Received
25 June 2005
Publication Date:
26 July 2005 (online)
Publication History
Publication Date:
26 July 2005 (online)
Abstract
A rapid synthesis of aryl azides from the corresponding aryl halides catalyzed by CuI/diamine is described. Sodium ascorbate was found to have a positive effect on stabilization of the catalyst system. The reactions were performed under very mild conditions generally with high yields. In the case of aryl iodides, the transformation could be carried out at room temperature.
Key words
copper - aryl azides - aryl halides - ligands - azidonation
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