Synlett 2005(14): 2236-2238  
DOI: 10.1055/s-2005-872236
LETTER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of the C19-C26 Segment of Amphidinolide H2

Florian P. Liesener, Markus Kalesse*
Universität Hannover, Institut für Organische Chemie, Schneiderberg 1B, 30167 Hannover, Germany
Fax: +49(511)7623011; e-Mail: Markus.Kalesse@oci.uni-hannover.de ;
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Publication History

Received 5 June 2005
Publication Date:
20 July 2005 (online)

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Abstract

The synthesis of the C19-C26 methyl ketone of amphidinolide H2 is described employing a stereoselective catalytic vinylogous Mukaiyama aldol reaction. Selective dihydroxylation and deoxygenation completes the synthesis of the C19-C26 segment.