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Synthesis 2005(15): 2597-2601  
DOI: 10.1055/s-2005-872073
PAPER
© Georg Thieme Verlag Stuttgart · New York

Three-Component Procedure for the Synthesis of 5-Aryl-5,8-dihydroazolo[1,5-a]pyrimidine-7-carboxylic Acids

Valentin A. Chebanov*, Yana I. Sakhno, Sergey M. Desenko, Svetlana V. Shishkina, Vladimir I. Musatov, Oleg V. Shishkin, Irina V. Knyazeva
Department of Photoactive Heterocyclic Compounds, State Scientific Institution ‘Institute for Single Crystals’, Institute for Scintillation Materials of National Academy of Sciences of Ukraine, Lenin Ave 60, Kharkiv 61001 Ukraine
Fax: +38(572)3409343; e-Mail: chebanov@isc.kharkov.com;
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Publication History

Received 14 March 2005
Publication Date:
18 July 2005 (online)

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Abstract

Three-component condensation of pyruvic acid with aromatic aldehydes and some aminoazoles was developed as a procedure for the synthesis 5-aryl-5,8-dihydroazolo[1,5-a]pyrimidine-7-carboxylic acids. An influence of solvent type on the composition of the reaction products was found. The structures of the compounds obtained were proved by 1H and 13C NMR spectroscopy, NOE experiments, and X-ray analysis.

Key words

heterocycles - multi-component reactions - pyruvic acid­ - aminoazoles - dihydropyrimidine derivatives

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