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Synthesis 2005(15): 2479-2481
DOI: 10.1055/s-2005-872072
DOI: 10.1055/s-2005-872072
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
An Easy Two-Step Reduction of Salicylic Acids and Alcohols to 2-Methylphenols
Further Information
Received
26 April 2005
Publication Date:
18 July 2005 (online)
Publication History
Publication Date:
18 July 2005 (online)
Abstract
Salicylic acids and alcohols can be reduced to 2-methylphenols by a simple two steps procedure. Reaction conditions were optimized carrying out a study on the solvent effect and the amount of the reducing agent. The improved procedure resulted particularly useful in the synthesis of deuterated building blocks of biological interest.
Key word
reductions - deoxygenation - hydrides - phenols - hydrogenations
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