RSS-Feed abonnieren
DOI: 10.1055/s-2005-870861
© Georg Thieme Verlag Stuttgart · New York
Gastroenterologie/Hepatologie - Licht und Dunkel im Verdauungstrakt
Effekte von Technik, Genetik und BiologieGastroenterology/hepatology - Light and darkness in the digestive tractDevelopments by technology, genetics and biologyPublikationsverlauf
Publikationsdatum:
16. Juni 2005 (online)

Die letzten Jahrzehnte haben faszinierende neue Entwicklungen im Bereich der Medizintechnik ebenso wie der Genetik und der Molekular- und Zellbiologie ergeben. Von Zeit zu Zeit muss daher gefragt werden, inwieweit sich diese neuen Erkenntnisse aus der Grundlagenforschung in klinisch fassbare Fortschritte haben umsetzen lassen. Dies kann hier nur in summarischer Weise geschehen, wobei einzelne Aspekte nach zweifelsohne subjektiver Auswahl hervorgehoben werden.
Literatur
- 1
Schiefke I, Zabel-Langhennig A, Neumann S, Feisthammel J, Moessner J, Caca K.
Long term failure of endoscopic gastroplication (EndoCinch).
Gut.
2005;
54
752-758
Reference Ris Wihthout Link
- 2
Barr H, Stone N, Rembacken B.
Recent advances in clinical practice: Endoscopic therapy of Barett’s oesophagus.
Gut.
2005;
54
875-884
Reference Ris Wihthout Link
- 3
Dulai G S, Shekelle P G, Jensen D M, Spiegel B MR, Chen J, Oh D, Kahn K L.
Dysplasia and risk of further neoplastic progression in a regional veterans administration
Barrett’s cohort.
Am J Gastroenterol.
2005;
100
775-783
Reference Ris Wihthout Link
- 4
Spechler S J.
Dysplasia in Barrett’s esophagus: limitations of current management strategies.
Am J Gastroenterol.
2005;
100
927-935
Reference Ris Wihthout Link
- 5
Crowe S E.
Helicobacter infection, chronic inflammation, and the development of malignancy.
Curr Opin Gastroenterol.
2005;
21
32-38
Reference Ris Wihthout Link
- 6
Nardone G, Rocco A, Malfertheiner P.
Helicobacter pylori and molecular events in precancerous gastric lesions.
Aliment Pharmacol Ther.
2004;
20
261-270
Reference Ris Wihthout Link
- 7
Chan A O, Lam S K, Wong B C. et al .
Promoter methylation of E-cadherin gene in gastric musoca associated with Helicobacter
pylori infection and in gastric cancer.
Gut.
2003;
52
261-270
Reference Ris Wihthout Link
- 8
Carneiro F, Huntsman D G, Smyrk T C. et al .
Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers
and its implications for patient screening.
J Pathol.
2004;
203
681-687
Reference Ris Wihthout Link
- 9
Higashi H, Nakaya A, Tsutsumi R. et al .
Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2
recruitment and activation.
J Biol Chem.
2004;
279
17 205-17 216
Reference Ris Wihthout Link
- 10
Rad R, Dossumbekova A, Neu B. et al .
Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation,
and host specific colonisation during Helicobacter pylori infection.
Gut.
2004;
53
1082-1089
Reference Ris Wihthout Link
- 11
Graham D Y, Shiotani A.
The time to eradicate gastric cancer is now.
Gut.
2005;
54
735-738
Reference Ris Wihthout Link
- 12
Nagar A B, Gorelick F S.
Acute pancreatitis.
Curr Opin Gastroenterol.
2004;
20
439-443
Reference Ris Wihthout Link
- 13
DiMagno M J, DiMagno E P.
Chronic pancreatitis.
Curr Opin Gastroenterol.
2004;
20
444-451
Reference Ris Wihthout Link
- 14
Kim K P, Kim M H, Song M H, Lee S S, Seo D W, Lee S K.
Autoimmune chronic pancreatitis.
Am J Gastroenterol.
2004;
99
1605-1616
Reference Ris Wihthout Link
- 15
Arvanitakis M, Delhaye M, De Maertelaere V. et al .
Computer tomography and magnetic resonance imaging in the assessment of acute pancreatitis.
Gastroenterology.
2004;
126
715-723
Reference Ris Wihthout Link
- 16
Pietrangelo A.
Hereditary hemochromatosis - a new look at an old disease.
N Engl J Med.
2004;
350
2383-2397
Reference Ris Wihthout Link
- 17
Sass D A, Chang P, Chopra K B.
Nonalcoholic fatty liver disease: a clinical review.
Dig Dis Sci.
2005;
50
171-180
Reference Ris Wihthout Link
- 18
Ratziu V, Poynard T.
NASH: a hidden and silent fibroser finally revealed?.
J Hepatol.
2005;
42
12-14
Reference Ris Wihthout Link
- 19
Adams L A, Schuyler S, Lindor K D, Angulo P.
The histological course of nonalcoholic fatty liver disease: a longitudinal study
of 103 patients with sequential liver biopsies.
J Hepatol.
2005;
42
132-138
Reference Ris Wihthout Link
- 20
Kaser S, Moschen A, Cayon A, Kaser A, Crespo J, Pons-Romero F, Ebenbichler C F, Patsch J R, Tilg H.
Adiponectin and its receptors in non-alcoholic steatohepatitis.
Gut.
2005;
54
117-121
Reference Ris Wihthout Link
- 21
Javor E D, Ghany M G, Cochran E K, Oral E A, DePaoli A M, Premkumar A, Kleiner D E, Gorden P.
Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy.
Hepatology.
2005;
41
753-760
Reference Ris Wihthout Link
- 22
Adams L A, Zein C, Angulo P, Lindor K D.
A pilot trial of pentoxifylline in nonalcoholic steatohepatitis.
Am J Gastroenterol.
2004;
99
2365-2368
Reference Ris Wihthout Link
- 23
Uygun A, Kadayifci A, Isik A T, Ozgurtas T, Deveci S, Tuzun A, Yesilova Z, Gulsen M, Dagalp K.
Metformin in the treatment of patients with non-alcoholic steatohepatitis.
Aliment Pharmacol Ther.
2004;
19
537-544
Reference Ris Wihthout Link
- 24
Nair S, Diehl A M, Wiseman M, Farr G H, Perrillo R P.
Metformin in the tretment of non-alcoholic steatohepatitis: a pilot label trial.
Aliment Pharmacol Ther.
2004;
20
23-28
Reference Ris Wihthout Link
- 25
Tilg H, Kaser A.
Treatment strategies in nonalcoholic fatty liver disease.
Nat Clin Pract Gastr.
2005;
2
148-155
Reference Ris Wihthout Link
- 26
Charlton M.
Nonalcoholic Fatty liver disease: a review of current understanding and future impact.
Clin Gastroenterol Hepatol.
2004;
2
1048-1058
Reference Ris Wihthout Link
- 27
Schepke M, Kleber G, Nurnberg D, Willert J, Koch L, Veltzke-Schlieker W, Hellerbrand C, Kuth J, Schanz S, Kahl S, Fleig W E, Sauerbruch T.
Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis.
Hepatology.
2004;
40
65-72
Reference Ris Wihthout Link
- 28
Sarin S K, Wadhawan M, Agarwal S R, Tyagi P, Sharma B C.
Endoscopic variceal ligation plus propranolol versus endoscopic variceal ligation
alone in primary prophylaxis of variceal bleeding.
Am J Gastroenterol.
2005;
100
797-804
Reference Ris Wihthout Link
- 29
Garcia-Tsao G.
Portal hypertension.
Curr Opin Gastroenterol.
2005;
21
313-322
Reference Ris Wihthout Link
- 30
Llovet J M.
Updated treatment approach to hepatocellular carcinoma.
J Gastroenterol.
2005;
40
225-235
Reference Ris Wihthout Link
- 31
Bruix J, Sala M, Llovet J M.
Chemoembolization for hepatocellular carcinoma.
Gastroenterology.
2004;
127
S179-S188
Reference Ris Wihthout Link
- 32
Bernatik T, Becker D, Neureiter D, Hansler J H, Frieser M, Schaber S, Wein A, Hahn E G, Strobel D.
Hepatic transit time of an echo enhancer: an indicator of metastatic spread to the
liver.
Eur J Gastroenterol Hepatol.
2004;
16
313-317
Reference Ris Wihthout Link
- 33
Schlottmann K, Kratzer W, Schölmerich J.
Doppler ultrasound and intravenous contrast agents in gastrointestinal tract disorders:
current role and future implications.
Eur J Gastroenterol Hepatol.
2005;
17
263-275
Reference Ris Wihthout Link
- 34
Tsai C J, Leitzmann M F, Willet W C, Giovannucci E L.
Dietary carbohydrates and glycaemic load and the incidence of symptomatic gall stone
disease in men.
Gut.
2005;
54
823-828
Reference Ris Wihthout Link
- 35
Schreiber S, Rosenstiel P, Albrecht M, Hampe J, Krawczak M.
Genetics of Crohn disease, an archetypal inflammatory barrier.
Nat Rev Genet.
2005;
6
376-388
Reference Ris Wihthout Link
- 36
Török H P, Glas J, Tonenchi L, Lohse P, Müller-Myhsok B, Limbersky O, Neugebauer C, Schnitzler F, Seiderer J, Tillack C, Brand S, Brünnler S, Jagiello P, Epplen J T, Griga T, Klein W, Schiemann U, Folwaczny M, Ochsenkühn T, Folwaczny C.
Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn’s disease.
Gut.
2005;
im Druck
Reference Ris Wihthout Link
- 37
Noble C L, Nimmo E R, Drummond H, Smith L, Arnott I D, Satsangi J.
DLG5 variants do not influence susceptibility to inflammatory bowel disease in the
Scottish population.
Gut.
2005;
im Druck
Reference Ris Wihthout Link
- 38
Watanabe T, Kitani A, Murray P J, Strober W.
NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses.
Nat Immunol.
2004;
5
776-778
Reference Ris Wihthout Link
- 39
Wehkamp J, Harder J, Weichenthal M, Schwab M, Schaffeler E, Schlee M, Herrlinger K R, Stallmach A, Noack F, Fritz P, Schroder J M, Bevins C L, Fellermann K, Stange E F.
NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal
alpha-defensin expression.
Gut.
2004;
53
1558-1560
Reference Ris Wihthout Link
- 40
Kobayashi K S, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nuñez G, Flavell R A.
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract.
Science.
2005;
307
731-734
Reference Ris Wihthout Link
- 41
Maeda S, Hsu L C, Liu H, Bankston L A, Iimura M, Kagnoff M F, Eckmann L, Karin M.
Nod2 mutation in Crohn’s disease potentiates NF-κB activity and IL-1β processing.
Science.
2005;
307
734
Reference Ris Wihthout Link
- 42
Eckmann L.
Defence molecules in intestinal innate immunity against bacterial infections.
Curr Opin Gastroenterol.
2005;
21
147-151
Reference Ris Wihthout Link
- 43
Wehkamp J, Harder J, Wehkamp K, Wehkamp-von Meissner B, Schlee M, Enders C, Sonnenborn U, Nuding S, Bengmark S, Fellermann K, Schroder J M, Stange E F.
NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial
cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium.
Infect Immun.
2004;
72
5750-5758
Reference Ris Wihthout Link
- 44 Schölmerich J. Biological therapies. In: Bernstein, C. (Ed.): IBD-yearbook 2005: im Druck
Reference Ris Wihthout Link
- 45
Ljung T, Karlen P, Schmidt D, Hellstrom P M, Lapidus A, Janczewska I, Sjoqvist U, Lofberg R.
Infliximab in inflammatory bowel disease: clinical outcome in a population based cohort
from Stockholm County.
Gut.
2004;
53
849-853
Reference Ris Wihthout Link
- 46
Colombel J F, Loftus E V, Tremaine W J, Egan L J, Harmsen W S, Schleck C D, Zinsmeister A R, Sandborn W J.
The safety profile of infliximab in patients with Crohn’s disease: the Mayo clinic
experience in 500 patients.
Gastroenterology.
2004;
126
19-31
Reference Ris Wihthout Link
- 47
Van den Brande J, Hommes D W, Peppelenbosch M P.
Infliximab induced T lymphocyte apoptosis in Crohn’s disease.
J Rheumatol Suppl.
2005;
74
26-30
Reference Ris Wihthout Link
- 48
Schreyer A G, Geissler A, Albrich H, Schölmerich J, Feuerbach S, Rogler G, Völk M, Herfarth H.
Abdominal MRI after enteroclysis or with oral contrast in patients with suspected
or proven Crohn’s disease.
Clin Gastroenterol Hepatol.
2004;
2
491-497
Reference Ris Wihthout Link
- 49
Schreyer A G, Gölder S, Scheibl K, Völk M, Lenhart M, Timmer A, Schölmerich J, Feuerbach S, Rogler G, Herfarth H, Seitz J.
Dark lumen magnetic resonance enteroclysis in combination with MRI colonography for
whole bowel assessment in patients with Crohn’s disease: first clinical experience.
Inflamm Bowel Dis.
2005;
11
388-394
Reference Ris Wihthout Link
- 50
Schreyer A G, Rath H C, Kikinis R, Völk M, Schölmerich J, Feuerbach S, Rogler G, Seitz J, Herfarth H.
Comparison of magnetic resonance imaging colonography with conventional colonoscopy
for the assessment of intestinal inflammation in patients with inflammatory bowel
disease: a feasibility study.
Gut.
2005;
54
250-256
Reference Ris Wihthout Link
- 51
Gölder S K, Schreyer A G, Endlicher E, Feuerbach S, Schölmerich J, Kullmann F, Seitz J, Rogler G, Herfarth H.
Comparison of capsule endoscopy and magnetic resonance (MR) enteroclysis in suspected
small bowel disease.
Int J Colorectal Dis.
2005;
im Druck
Reference Ris Wihthout Link
- 52
Hartmann D, Schmidt H, Bolz G, Schilling D, Kinzel F, Eickhoff A, Huschner W, Möller K, Jakobs R, Reitzig P, Weickert U, Gellert K, Schultz H, Guenther K, Hollerbuhl H, Schoenleben K, Schulz H -J, Riemann J F.
A prospective two-center study comparing wireless capsule endoscopy with intraoperative
enteroscopy in patients with obscure gastrointestinal bleeding.
Gastrointest Endosc.
2005;
im Druck
Reference Ris Wihthout Link
- 53
Keroack M.
Video capsule endoscopy.
Curr Opin Gastroenterol.
2004;
20
474-481
Reference Ris Wihthout Link
- 54
Gionchetti P, Morselli C, Rizzello F, Romagnoli R, Campieri M, Poggioli G, Laureti S, Ugolini F, Pierangeli F.
Management of pouch dysfunction or pouchitis with an ileoanal pouch.
Best Pract Res Clin Gastroenterol.
2004;
18
993-1006
Reference Ris Wihthout Link
- 55
Kruis W, Fric P, Pokrotnicks J, Lukas M, Fixa B, Kascak M, Kamm M A, Weismueller J, Beglinger C, Stolte M, Wolff C, Schulze J.
Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle
1917 is as effective as with standard mesalazine.
Gut.
2004;
53
1617-1623
Reference Ris Wihthout Link
- 56
Hart A L, Lammers K, Brigidi P, Vitali B, Rizzello F, Gionchetti P, Campieri M, Kamm M A, Knight S C, Stagg A J.
Modulation of human dendritic cell phenotype and function by probiotic bacteria.
Gut.
2004;
53
1602-1609
Reference Ris Wihthout Link
- 57
Summers R W, Elliott D E, Urban J F, Thompson R A, Weinstock J V.
Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial.
Gastroenterology.
2005;
128
1117-1119
Reference Ris Wihthout Link
- 58
Summers R W, Elliott D E, Urban J F, Thompson R A, Weinstock J V.
Trichuris suis therapy in Crohn’s disease.
Gut.
2005;
54
87-90
Reference Ris Wihthout Link
- 59
Schoenfeld P, Cash B, Flood A, Dobhan R, Eastone J, Coyle W, Kikendall J W, Kim H M, Weiss D G, Emory T, Schatzkin A, Lieberman D.
Colonoscopic screening of average-risk women for colorectal neoplasia.
N Engl J Med.
2005;
352
2061-2068
Reference Ris Wihthout Link
- 60
Agrawal J, Syngal S.
Colon cancer screening strategies.
Curr Opin Gastroenterol.
2005;
21
59-63
Reference Ris Wihthout Link
- 61
Fletcher J G, Booya F, Johnson C D, Ahlquist D.
CT colonography: unraveling the twists and turns.
Curr Opin Gastroenterol.
2005;
21
90-98
Reference Ris Wihthout Link
- 62
Riemann J F.
Gastroenterologie: Neue Denkgebäude, faszinierende Wege und Schnittstelle zur Chirurgie.
Dtsch Med Wochenschr.
1999;
124
1546-1549
Reference Ris Wihthout Link
Prof. Dr. Jürgen Schölmerich
Klinik und Poliklinik für Innere Medizin I der Universität Regensburg
Klinikum
93042 Regensburg
Telefon: 0941/9447000
Fax: 0941/9447002
eMail: juergen.schoelmerich@klinik.uni-r.de