Synthesis of 3-Nitro-1H-indole-2-carboxylic Acid Ethyl Ester Derivatives from Baylis-Hillman Adducts

Clemens R. Horn; Michel Perez

doi:10.1055/s-2005-868499

LETTER

Synthesis of 3-Nitro-1H-indole-2-carboxylic Acid Ethyl Ester Derivatives from Baylis-Hillman Adducts

Clemens R. Horn, Michel Perez*
Pierre Fabre Research Center, 17 Avenue Jean Moulin, 81106 Castres, France
Fax: +33(5)63714299; e-Mail: michel.perez@pierre-fabre.com;

Abstract

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Abstract

A simple and direct synthesis of 3-nitro-1H-indole-2-carboxylic acid ethyl ester derivatives from acetylated Baylis-Hillman adducts of 2-nitrobenzaldehydes is described.

Key words

indoles - heterocycle - rearrangement - ring-closure - Baylis-Hillman

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References

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