An Efficient Method for the Protection of Alcohols and Phenols by Using Hexamethyldisilazane in the Presence of Cupric Sulfate Pentahydrate under Neutral Reaction Conditions

Batool Akhlaghinia; Sedigheh Tavakoli

doi:10.1055/s-2005-865318

PAPER

An Efficient Method for the Protection of Alcohols and Phenols by Using Hexamethyldisilazane in the Presence of Cupric Sulfate Pentahydrate under Neutral Reaction Conditions

Batool Akhlaghinia*, Sedigheh Tavakoli
Department of Chemistry, Damghan University of Basic Sciences, Damghan, Iran
Fax: +98(232)5244787; e-Mail: b_akhlaghinia@dubs.ac.ir;

Abstract

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Abstract

Alcohols and phenols are protected with hexamethyldisilazane in the presence of cupric sulfate pentahydrate in good to excellent yields in acetonitrile. The method is highly selective for the conversion of primary alcohols in the presence of secondary and tertiary alcohols as well as phenols.

Keywords

cupric sulfate pentahydrate - HMDS - alcohol - phenol - trimethylsilylether

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Referenzen

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