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Synthesis 2005(9): 1491-1495
DOI: 10.1055/s-2005-865299
DOI: 10.1055/s-2005-865299
PAPER
© Georg Thieme Verlag Stuttgart · New YorkSynthesis and Biological Evaluation of E-Selectin Antagonists that Present Different Carbohydrate Ligands in a Multivalent Format
Further Information
Received
12 January 2005
Publication Date:
07 April 2005 (online)
Publication History
Publication Date:
07 April 2005 (online)
Abstract
The synthesis of the first polylysine conjugates that present different carbohydrate ligands in a multivalent format is reported. Glycopolymers 3c and 3d have been prepared with a highly predictable composition as indicated by 1H NMR. They function as multivalent E-selectin inhibitors but their potencies are not superior compared to previously-described related compounds.
Key words
sialyl Lewis X - slectins - glycopolymers - multivalency - carbohydrate chemistry
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