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Dtsch Med Wochenschr 2005; 130(14): 880-882
DOI: 10.1055/s-2005-865102
DOI: 10.1055/s-2005-865102
Prinzip & Perspektive
Gastroenterologie/Onkologie
© Georg Thieme Verlag Stuttgart · New York
Kolonkarzinom: Molekulare Marker
Colon cancer: molecular markersFurther Information
Publication History
eingereicht: 11.10.2004
akzeptiert: 18.2.2005
Publication Date:
31 March 2005 (online)

Glossar
CRC = kolorektales Karzinom
CIN = chromosomale Instabilität
MSI = Mikrosatelliteninstabilität
Literatur
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- 2 Arnold C N, Blum H E. Molekulare Pathogenese des Kolonkarzinoms: Klinische Relevanz. Dtsch Med Wochenschr. 2005; 130 809-811
- 3 Arnold C N, Goel A, Boland C R. Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines. Int J Cancer. 2003; 106 66-73
- 4 Barratt P L, Seymour M T, Stenning S P. et al . DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: a molecular study. Lancet. 2002; 360 1381-1391
- 5 Calistri D, Rengucci C, Bocchini R, Saragoni L, Zloi W, Amadori D. Fecal multiple molecular tests to detect colorectal cancer in stool. Clin Gastro Hepatol. 2003; 1 377-383
- 6 Carethers J M, Smith E J, Behing C A. et al . Use of 5-fluorouracil and survival in patients with microsatellite unstable colorectal cancer. Gastroenterology. 2004; 126 394-401
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- 8 Fallik D, Borrini F, Boige V. et al . Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer. Cancer Res. 2003; 63 5738-5744
- 9 Müller H M, Oberwalder M, Fiegl H. et al . Methylaion changes in faecal DNA: a marker for colorectal screenng?. Lancet. 2004; 363 1283-1285
- 10 Ribic C M, Sargent D J, Moore M J. et al . Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med. 2003; 349 247-257
- 11 Sidransky D, Tokino T, Hamilton S R. et al . Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. Science. 1992; 256 102-105
- 12 Traverso G, Shuber A, Levin B. et al . Detection of APC mutations in fecal DNA from patients with colorectal tumors. N Engl J Med. 2002; 346 311-320
- 13 Traverso G, Shuber A, Olsson L. et al . Detection of proximal colorectal cancers through analysis of faecal DNA. Lancet. 2002; 359 403-404
- 14 Watanabe T, Wu T T, Catalano P J. et al . Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med. 2001; 344 1196-1206
- 15 Zhou W, Goodman S N, Galizia G. et al . Counting alleles to predict recurrence of early-stage colorectal cancers. Lancet. 2002; 359 219-225
Dr. med. Christian N. Arnold
Medizinische Universitätsklinik Freiburg, Abteilung Innere Medizin II
Hugstetter Straße 55
79106 Freiburg
Phone: 0761/2703401
Fax: 0761/2703655
Email: arnold@med1.ukl.uni-freiburg.de