Easy Copper-, Ligand- and Amine-Free Sonogashira Coupling Reaction Catalyzed by Palladium on Carbon at Low Catalyst Loading and by Exposure to Air

Guolin Zhang

doi:10.1055/s-2005-863720

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Synlett 2005(4): 619-622
DOI: 10.1055/s-2005-863720

LETTER

Easy Copper-, Ligand- and Amine-Free Sonogashira Coupling Reaction Catalyzed by Palladium on Carbon at Low Catalyst Loading and by Exposure to Air

Guolin Zhang*
Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, P. R. China
Fax: +86(571)87217412; e-Mail: guolinzhang@zju.edu.cn;

Further Information

Publication History

Received 27 October 2004
Publication Date:
22 February 2005 (online)

Abstract
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Abstract

An easy copper-, ligand and amine-free Sonogashira coupling reaction catalyzed by commercially available palladium on carbon with air at low catalyst loading (0.2 mol% Pd) has been developed. Aryl iodides coupled with aromatic alkynes gave good to excellent yields and with aliphatic alkyne gave moderate to good yields. The reaction system is easy to handle.

Key words

Sonogashira coupling - palladium - catalysis - heterogeneous

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