Synthesis of Functionalized Benzo-18-Crown-6 Compounds via the Suzuki-Miyaura Cross-Coupling Reaction

Sambasivarao Kotha; Dhurke Kashinath

doi:10.1055/s-2005-861840

PAPER

Synthesis of Functionalized Benzo-18-Crown-6 Compounds via the Suzuki-Miyaura Cross-Coupling Reaction

Sambasivarao Kotha*, Dhurke Kashinath
Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai-400076, India
Fax: +91(22)25723480; e-Mail: srk@chem.iitb.ac.in;

Abstract

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Abstract

Various functionalized 4′-and 4′,5′-benzo-18-crown-6 compounds have been synthesized using the palladium-catalyzed Suzuki-Miyaura cross-coupling reaction as a key step. Treatment of the bromobenzocrowns with various arylboronic acids in presence of palladium-catalyst and aqueous Na₂CO₃ gave the biphenyl-based benzocrowns in good yields.

Key Words

benzocrown ethers - Suzuki-Miyaura cross-coupling - boronic acids - palladium - macromolecules

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