CosmoDerm/CosmoPlast (Human Bioengineered Collagen) for the Aging Face

ABSTRACT

Type 1 collagen loss in the dermis is one of the primary causes of wrinkles seen in aged skin. Dermal fillers using type 1 collagen derived from bioengineered skin are now being used to treat facial wrinkles. These fillers, known by the trade names of CosmoDerm and CosmoPlast, can be used alone or in combination with hyaluronic acid fillers. The benefit of collagen-based dermal fillers is decreased downtime, decreased bruising, decreased pain on injection, and the ability to return lost structural components to aged skin. Many aesthetic physicians are beginning to use collagen- and hyaluronic-containing fillers in combination to replace both of these natural components of the skin that are lost during the aging process.

KEYWORDS

Collagen - elastin - hyaluronic acid - dermal filler - CosmoPlast - CosmoDerm - Hylaform - Restylane - Captique - Juvederm - photoaging - wrinkles - bioengineered

REFERENCES

• 1 Gniadecka M, Nielsen O F, Wessel S et al.. Water and protein structure in photoaged and chronically aged skin.  J Invest Dermatol. 1998;  111 1129-1133
• 2 Fenske N A, Lober C W. Functional and structural changes of normal aging skin.  J Am Acad Dermatol. 1986;  15 571-585
• 3 Lovell C R, Smolenski K A, Duance V C et al.. Type I and III collagen content and fibre distribution in normal human skin during ageing.  Br J Dermatol. 1987;  117 419-428
• 4 Fisher G J, Wang Z Q, Datta S C et al.. Pathophysiology of premature skin aging induced by ultraviolet light.  N Engl J Med. 1997;  337 1419-1428
• 5 Griffiths C E, Russman A N, Majmudar G et al.. Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid).  N Engl J Med. 1993;  329 530-535
• 6 Lavker R M. Structural alterations in exposed and unexposed aged skin.  J Invest Dermatol. 1979;  73 59-66
• 7 Shuster S, Black M M, McVitie E. The influence of age and sex on skin thickness, skin collagen and density.  Br J Dermatol. 1975;  93 639-643
• 8 Ghersetich I, Lotti T, Campanile G, Grappone C, Dini G. Hyaluronic acid in cutaneous intrinsic aging. Int Journal Derm 1994 113: 119-122
• 9 Baumann L. Cigarettes and aging skin. In: Baumann L Cosmetic Dermatology: Principles and Practice. Philadelphia; McGraw Hill 2002: 21-25
• 10 Kang S, Chung J H, Lee J H et al.. Topical n-acrtyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo .  J Invest Dermatol. 2003;  120 835-841
• 11 Okada S, Hagan J, Kato M et al.. Lidocaine and its analogues inhibit IL-5 mediated survival and activation of human eosinophils.  J Immunol. 1998;  160 4010-4017
• 12 Panel Proceedings Nov FDA. 21 2003
• 13 Narins R S, Brandt F, Leyden J, Lorenc Z P, Rubin M, Smith S. A randomised, double-blind, multicenter comparison of the efficacy and tolerability of Restylane^™ versus Zyplast for the correction of nasolabial folds.  Dermatol Surg. 2003;  29 588-595
• 14 Panel Proceedings Nov FDA. 21 2003