Synlett 2005(3): 437-440  
DOI: 10.1055/s-2004-837221
LETTER
© Georg Thieme Verlag Stuttgart · New York

First Total Synthesis of Caminoside A, an Antimicrobial Glycolipid from Sponge

Jiansong Suna, Xiuwen Hana, Biao Yu*b
a State Key Laboratory of Catalyst, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China
b State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China
e-Mail: byu@mail.sioc.ac.cn;
Further Information

Publication History

Received 18 November 2004
Publication Date:
22 December 2004 (online)

Abstract

Caminoside A, a novel antimicrobial tetrasaccharide ­glycolipid from the marine sponge Caminus sphaeroconia, which represents the first bacterial type III secretion inhibitor, is syn­thesized in a total of 57 steps starting from d-glucose, d-galactose, l-rhamnose, and 9-decenal.