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DOI: 10.1055/s-2004-835292
© Georg Thieme Verlag Stuttgart · New York
Bedeutung der arteriellen Hypertonie für Augenerkrankungen
The importance of systemic hypertension for eye diseasesPublikationsverlauf
eingereicht: 30.8.2004
akzeptiert: 27.10.2004
Publikationsdatum:
09. November 2004 (online)

Durch die zunehmende Altersentwicklung werden chronische Erkrankungen in den nächsten Jahren bei der Versorgung der Bevölkerung an Bedeutung gewinnen. Dabei werden Erkrankungen des Auges eine maßgebliche Rolle spielen. In einer kürzlich durchgeführten Longitudinalstudie stieg die Häufigkeit in einer Altersgruppe mit durchschnittlich 65 Jahren entweder einer diabetischen Retinopathie, einer altersbedingten Makuladegeneration oder eines Glaukoms im Laufe von 9 Jahren von 13,4 auf 45,4 % [28] an. Diese drei Augenkrankheiten repräsentieren auch in Deutschland die drei häufigsten Erblindungsursachen [27], so dass es wichtig ist, diese Krankheiten frühzeitiger zu diagnostizieren und besser therapeutisch einzustellen. Dabei besitzt die arterielle Hypertonie als „internistische Volkskrankheit” eine herausragende Bedeutung als Risikofaktor für zahlreiche Augenkrankheiten.
Literatur
- 1
Ahmetoglu A, Erdol H, Simsek A, Gokce M, Dinc H, Gumele H R.
Effect of hypertension and candesartan on the blood flow velocity of the extraocular
vessels in hypertensive patients.
Eur J Ultrasound.
2003;
16
177-182
Reference Ris Wihthout Link
- 2
Alm A, Bill A.
Ocular and optic nerve blood flow at normal and increased intraocular pressures
in monkeys (Macaca irus): a study with radioactively labelled microspheres including
flow determinations in brain and some other tissues.
Exp Eye Res.
1973;
15
15-29
Reference Ris Wihthout Link
- 3
Aoki N, Horibe H, Ohno Y, Hayakawa N, Kondo R.
Epidemiological evaluation of fundoscopic findings in cerebrovascular diseases.
III. Observer variability and reproducibility for fundoscopic findings.
Jpn Circ J.
1977;
41
11-17
Reference Ris Wihthout Link
- 4
Bill A, Sperber G O.
Control of retinal and choroidal blood flow.
Eye.
1990;
4
319-325
Reference Ris Wihthout Link
- 5
Bonomi L, Marchini G, Marraffa M, Bernardi P, Morbio R, Varotto A.
Vascular risk factors for primary open angle glaucoma. The Egna-Neumarkt Study.
Ophthalmology.
2000;
107
1287-1293
Reference Ris Wihthout Link
- 6
Buono L M, Foroozan R, Sergott R C, Savino P J.
Nonarteritic anterior ischemic optic neuropathy.
Curr Opin Ophthalmol.
2002;
13
3357-3361
Reference Ris Wihthout Link
- 7
Chobanin A.
Adaptive and maladaptive responses of the arterial wall to hypertension.
Hypertension.
1990;
15
666-674
Reference Ris Wihthout Link
- 8
Cignarelli M, Luigia de Cicco M, Damato A. et al .
High systolic blood presssure increases prevalence and severity of retinopathy
in NIDDM patients.
Diabetes Care.
1992;
15
1002-1008
Reference Ris Wihthout Link
- 9
Dzau V Y, Gibbons G H.
Vascular remodeling: mechanisms and implications.
J Cardiovasc Pharmacol.
1993;
21
1-5
(suppl 1)
Reference Ris Wihthout Link
- 10
Elman M J, Bhatt A K, Quinlan P M, Enger C.
The risk for systemic vascular diseases and mortality in patients with central
retinal vein occlusion.
Ophthalmology.
1990;
97
1543-1548
Reference Ris Wihthout Link
- 11
Fuchsjäger-Mayrl G, Wally B, Georgopoulos M. et al .
Ocular blood flow and systemic blood pressure in patients with primary open-angle
glaucoma and ocular hypertension.
Invest Ophthalmol Vis Sci.
2004;
45
834-839
Reference Ris Wihthout Link
- 12
Greene A, Tonellato P J, Lui J, Lombard J H, Cowley A W.
Microvascular rarefication and tissue vascular resistence in hypertension.
Am J Physiol.
1989;
243
126-131
Reference Ris Wihthout Link
- 13 Greite J H. Hypertonie und Arteriosklerose aus ophthalmologischer Sicht. Stuttgart: Enke In: Naumann GOH, Merté HJ, Hollwich F, Gloor B (Hrsg.): Gefässerkrankungen des
Auges 1983: 55-70
Reference Ris Wihthout Link
- 14
Hacioglu G, Agar A, Ozkaya G, Yargicoglu P, Gumuslu S.
The effect of different hypertension models on visual evoked potentials.
Int J Neurosci.
2002;
112
1321-1335
Reference Ris Wihthout Link
- 15
Hansen-Smith F, Greene A S, Cowley A W, Lombard J H.
Structural changes during microvascular rarefication in chronic hypertension.
Hypertension.
1990;
15
922-928
Reference Ris Wihthout Link
- 16
Hayreh S S, Jonas J B.
Appearance of the optic disk and retinal nerve fiber layer in atherosclerosis
and arterial hypertension: an experimental study in rhesus monkeys.
Am J Ophthalmol.
2000;
130
91-96
Reference Ris Wihthout Link
- 17
Hayreh S S, Podhajsky P, Zimmerman M B.
Role of nocturnal arterial hypotension in optic nerve head ischemic disorders.
Ophthalmologica.
1999;
213
76-96
Reference Ris Wihthout Link
- 18
Hayreh S S, Servaisn G E, Virdi P S.
Fundus lesions in malignant hypertension (VI). Hypertensive choroidopathy.
Ophthalmology.
1986;
93
1383-1400
Reference Ris Wihthout Link
- 19
Heidbreder E, Huller U, Schafer B. et al .
Severe hypertensive retinopathy: Increased incidence in renoparenchymal hypertension.
Am J Nephrol.
1987;
7
394-400
Reference Ris Wihthout Link
- 20
Hoyer J.
Blutdruckabhängige Änderungen der Aktivität retinaler Ganglienzellen.
Klin Monatsbl Augenheilkd.
1975;
166
185-189
Reference Ris Wihthout Link
- 21
Hubbard L D, Brothers R J, King W N, Clegg L X, Klein R, Cooper L S, Sharrett A R, Davis M D, Cai J.
Methods for evaluation of retinal microvascular abnormalities associated with
hypertension/sclerosis in the atherosclerosis risk in communities study.
Ophthalmology.
1999;
106
2269-2280
Reference Ris Wihthout Link
- 22
Jampol L M.
Hypertension and visual outcomes in Macular Photocoagulation Study.
Arch Ophthalmol.
1991;
109
1232-1241
Reference Ris Wihthout Link
- 23 Joint National Committee on the Prevention, Detection, Evaluation, and Treatment
of High Blood Pressure .Sixth Report. NIH publication No 98 - 4080 1997
Reference Ris Wihthout Link
- 24
Keith N M, Wagener H P, Barker N W.
Some different types of essential hypertension: their course and prognosis.
Am J Med Sci.
1939;
197
332-343
Reference Ris Wihthout Link
- 25
Kiel J W.
Choroidal myogenic autoregulation and intraocular pressure.
Exp Eye Res.
1994;
58
529-543
Reference Ris Wihthout Link
- 26
Klein R, Klein B E, Moss S E, Cruickshanks K J.
The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XVII: the 14-year
incidence and progression of diabetic retinopathy and associated risk factors
in type 1 diabetes.
Ophthalmology.
1998;
105
1801-1815
Reference Ris Wihthout Link
- 27
Krumpaszky H G, Lüdtke R, Mickler A, Klauss V, Selbmann H K.
Blindness incidence in germany.
Ophthalmologica.
1999;
213
176-182
Reference Ris Wihthout Link
- 28
Lee P P, Feldman Z W, Ostermann J, Brown D S, Sloan F A.
Longitudinal prevalence of major eye diseases.
Arch Ophthalmol.
2003;
212
1303-1310
Reference Ris Wihthout Link
- 29
Locke L C.
Ocular manifestations of hypertension.
Optom Clin.
1992;
2
47-76
Reference Ris Wihthout Link
- 30 Lund O E. Über den Wert retinaler Gefäßveränderungen in der Diagnostik der Arteriosklerose. Basel:Karger 1964
Reference Ris Wihthout Link
- 31
Lund O E.
Fundus hypertonicus. Spiegel der Niere oder des Hirns?.
MMW.
1974;
12
613-616
Reference Ris Wihthout Link
- 32
Mangat H S.
Retinal artery occlusion.
Surv Ophthalmol.
1995;
40
145-156
Reference Ris Wihthout Link
- 33
Mc Leod D, Marshall J, Kohner E M. et al .
The role of axoplasmic transport in the pathogenesis of retinal cotton-wool
spots.
Br J Ophthalmol.
1977;
61
177-191
Reference Ris Wihthout Link
- 34
Nagel E, Vilser W, Lanzl I.
Age, blood pressure, and vessel diameter as factors influencing the arterial
retinal flicker response.
Invest Ophthalmol Vis Sci.
2004;
45
1486-1492
Reference Ris Wihthout Link
- 35
Pache M, Kube T, Wolf S, Kutschbach P.
Do angiographic data support a detailed classification of hypertensive fundus
changes?.
J Hum Hypertens.
2002;
16
405-410
Reference Ris Wihthout Link
- 36
Palatini P, Penzo M, Bongiovi S. et al .
Role of ophthalmoscopy in arterial hypertension: A problem revisited.
Cardiologia.
1991;
36
713-722
Reference Ris Wihthout Link
- 37
Pillunat L E, Anderson D R, Knighton R W, Joos K M, Feuer W J.
Autoregulation of human optic nerve head circulation in response to increased
intraocular pressure.
Exp Eye Res.
1997;
64
737-744
Reference Ris Wihthout Link
- 38
Portaluppi F, Boari B, Manfredini R.
Oxidative stress in essential hypertension.
Curr Pharm Des.
2004;
10
1695-1698
Reference Ris Wihthout Link
- 39
Rassam S M, Patel V, Kohner E M.
The effect of experimental hypertension on retinal vascular autoregulation in
humans: a mechanism for the progression of diabetic retinopathy.
Exp Physiol.
1995;
80
53-68
Reference Ris Wihthout Link
- 40
Robinson F, Riva C E, Grunwald J E, Petrig B L, Sinclair S H.
Retinal blood flow autoregulation: a response to an acute increase in blood
pressure.
Invest Ophthalmol.
1986;
27
722-726
Reference Ris Wihthout Link
- 41
Romero Aroca P, Fernandez Ballart J, Mendez Marin I, Salvat Serra M, Martinez Salcedo I.
Study of the relationship between retinal and renal microangiopathy in patients
with diabetes mellitus type II.
Rev Clin Esp.
2003;
206
268-272
Reference Ris Wihthout Link
- 42
Rüfer F, Schröder A, Winter R, Erb C.
Risikofaktorenanalyse und Therapievergleich zwischen Heparin und Hämodilution
bei Zentralarterienverschluss des Auges.
Ophthalmologe.
2003;
100
819-824
Reference Ris Wihthout Link
- 43
Schröder A, Erb C, Falk S, Schwartze G, Radermacher J, Winter R.
Farbsinnstörungen bei Patienten mit einer arteriellen Hypertonie.
Ophthalmologe.
2002;
99
375-379
Reference Ris Wihthout Link
- 44
Schröder A, Falk S, Wollstein J, Meyer M, Erb C.
Morphologie der Papille bei Patienten mit einer arteriellen Hypertonie.
Z prakt Augenheilkd.
2003;
24
376-378
Reference Ris Wihthout Link
- 45
Schulte K, Wolf S, Koch M J, Arend O, Remky A, Ittel T H, Reim M.
Retinale Hämodynamik bei Patienten mit arterieller Hypertonie.
Ophthalmologe.
1993;
90
479-485
Reference Ris Wihthout Link
- 46
Tielsch J M, Katz J, Sommer A, Quigley H A, Javitt J C.
Hypertension, perfusion pressure, and primary open-angle glaucoma.
Arch Ophthalmol.
1995;
113
216-221
Reference Ris Wihthout Link
- 47 Tso M OM, Abrams G W, Jampol L M. Hypertensive retinopathy, choroidopathy, and optic neuropathy: A clinical and
pathophysiological approach to classification. Baltimore: Williams and Wilkins In: Singerman LJ, Jampol LM, eds. Retinal and choroidal manifestations of systemic
disease 1991:7: 9-127
Reference Ris Wihthout Link
- 48
Van Leeuwen R, Ikram M K, Vingerling J R, Wittemann J C, Hofman A, de Jong P T.
Blood pressure, atherosclerosis, and the incidence of age-related maculopathy:
the Rotterdam Study.
Invest Ophthalmol Vis Sci.
2003;
44
377 137-77
Reference Ris Wihthout Link
- 49
Wolf S, Arend O, Schulte K, Ittel T H, Reim M.
Quantification of retinal capillary density and flow velocity in patients with
essential hypertension.
Hypertension.
1994;
23
464-467
Reference Ris Wihthout Link
- 50
Wong T Y, Hubbard L D, Klein R, Marino E K, Kronmal R, Sharrett A R, Siscovick D S, Burke G, Tielsch J M.
Retinal microvascular abnormalitis and blood pressure in older people: the Cardiovascular
Health Study.
Br J Ophthalmol.
2002;
86
1007-1013
Reference Ris Wihthout Link
- 51
Wong T Y, Klein R, Couper D J. et al .
Retinal microvascular abnormalities and incident stroke: The Atherosklerosis
Risk in Communities Study.
Lancet.
2001;
358
1134-1140
Reference Ris Wihthout Link
- 52
Wong T Y, Klein R, Sharrett A R. et al .
Retinal arteriolar narrowing and risk of coronary heart disease in men and women.
The Atherosclerosis Risk in Community Study.
J Am Med Assoc .
2002;
287
1153-1159
Reference Ris Wihthout Link
Priv.-Doz. Dr. Carl Erb
Augenklinik der Medizinische Hochschule Hannover
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