Efficient Chiral Pool Synthesis of the C1-C6 Fragment of Epothilones

Ulrich Klar; Bodo Röhr; Frank Kuczynski; Wolfgang Schwede; Markus Berger; Werner Skuballa; Bernd Buchmann

doi:10.1055/s-2004-834936

PAPER

Efficient Chiral Pool Synthesis of the C1-C6 Fragment of Epothilones

Ulrich Klar*, Bodo Röhr, Frank Kuczynski, Wolfgang Schwede, Markus Berger, Werner Skuballa, Bernd Buchmann
Research Laboratories of Schering AG, Müllerstrasse 170, 13342 Berlin, Germany
Fax: +49(30)46892635; e-Mail: ulrich.klar@schering.de;

Abstract

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Abstract

An efficient chiral pool synthesis of the C1-C6 fragment of epothilones starting from readily available
(-)-pantolactone is described.

Key words

epothilone - pantolactone - chiral pool synthesis

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Referenzen

References

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