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Synthesis 2005(2): 291-295
DOI: 10.1055/s-2004-834929
DOI: 10.1055/s-2004-834929
PAPER
© Georg Thieme Verlag Stuttgart · New YorkVersatile Synthesis of 3-Arylindan-1-ones by Palladium-Catalyzed Intramolecular Reductive Cyclization of Bromochalcones
Further Information
Received
5 July 2004
Publication Date:
24 November 2004 (online)
Publication History
Publication Date:
24 November 2004 (online)
Abstract
We have developed a novel and versatile synthesis of racemic 3-arylindan-1-ones by palladium-catalyzed intramolecular reductive cyclization of bromochalcones. This method is especially attractive because it avoids strong acidic conditions and consequently a larger number of sensitive functional groups are accepted during synthesis compared with existing methods.
Key words
3-arylindan-1-ones - palladium - reductive cyclization - chalcone - intramolecular
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