Versatile Synthesis of 3-Arylindan-1-ones by Palladium-Catalyzed Intramolecular Reductive Cyclization of Bromochalcones

Ask Püschl; Hans Christian Rudbeck; André Faldt; Allesia Confante; Jan Kehler

doi:10.1055/s-2004-834929

PAPER

Versatile Synthesis of 3-Arylindan-1-ones by Palladium-Catalyzed Intramolecular Reductive Cyclization of Bromochalcones

Ask Püschl*^a, Hans Christian Rudbeck^b, André Faldt^b, Allesia Confante^b, Jan Kehler^a
^a Medicinial Chemistry Research, H. Lundbeck A/S Ottiliavej 9, 2500, Denmark
Fax: +4536301385; e-Mail: askp@lundbeck.com;
^b Process Research, H. Lundbeck A/S Ottiliavej 9, 2500, Denmark

Abstract

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Abstract

We have developed a novel and versatile synthesis of racemic 3-arylindan-1-ones by palladium-catalyzed intramolecular reductive cyclization of bromochalcones. This method is especially attractive because it avoids strong acidic conditions and consequently a larger number of sensitive functional groups are accepted during synthesis compared with existing methods.

Key words

3-arylindan-1-ones - palladium - reductive cyclization - chalcone - intramolecular

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References

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