Synthesis 2005(5): 840-842  
DOI: 10.1055/s-2004-834887
PSP
© Georg Thieme Verlag Stuttgart · New York

Boronic Acids as Versatile Aryl Sources for the Highly Enantioselective Synthesis of Chiral Diarylmethanols on Multigram Scale

Jens Rudolph, Frank Schmidt, Carsten Bolm*
Institut für Organische Chemie, RWTH Aachen, Professor-Pirlet-Strasse 1, 52056 Aachen, Germany
Fax: +49(241)8092391; e-Mail: [email protected];
Further Information

Publication History

Received 16 July 2004
Publication Date:
21 October 2004 (online)

Abstract

Chiral diarylmethanols have been synthesized on gram scale in high yields with excellent enantioselectivities using a catalyst with a ferrocenyl oxazoline-based N,O-ligand and mixtures of diethylzinc and arylboronic acid as an aryl source.

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