Pulmonary Kaposi's Sarcoma In Pregnancy

Ann E. Bryant; Mehmet Genc; Rocío M. Hurtado; Katherine T. Chen

doi:10.1055/s-2004-831880

American Journal of Perinatology, Table of Contents

Am J Perinatol 2004; 21(6): 355-363
DOI: 10.1055/s-2004-831880

Pulmonary Kaposi's Sarcoma In Pregnancy

Ann E. Bryant¹ , Mehmet Genc¹ , Rocío M. Hurtado² ^, ³ , Katherine T. Chen¹

¹Department of Obstetrics, Gynecology, and Reproductive Medicine, Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts
²Department of Medicine, Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts
³Division of Infectious Disease at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

Abstract

Kaposi's sarcoma in human immunodeficiency virus (HIV) -infected women, often misdiagnosed, has an aggressive clinical course, with high rates of visceral involvement and decreased survival. We describe the first case of isolated pulmonary Kaposi's sarcoma in pregnancy. A nulliparous woman was diagnosed with AIDS after presenting at 25 weeks gestation with a cough and multiple pulmonary nodules. Extensive pulmonary evaluation was nondiagnostic until thorascopic lung biopsy revealed Kaposi's sarcoma. Despite combination antiretroviral therapy, her malignancy progressed. Labor was induced at 33.5 weeks gestation for nonreassuring fetal testing. She received chemotherapy postpartum and remains in remission. Pulmonary Kaposi's sarcoma should be considered in the differential diagnosis of HIV-infected obstetric patients with respiratory compromise. Definitive diagnosis is necessary given the aggressive clinical course that is potentially responsive to therapy.

KEYWORDS

Kaposi's sarcoma - pulmonary - HIV - pregnancy

Full Text

References

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Ann E BryantM.D. M.Sc.

Division of Maternal-Fetal Medicine, Northwestern University, Feinberg School of Medicine

Suite 410, 333 East Superior Street, Chicago, IL 60611