Synthesis 2004(16): 2614-2616  
DOI: 10.1055/s-2004-831259
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

A Concise Synthesis of 2,4-Disubstituted Pyridines: A Convenient Synthesis of 2-Bromo-4-iodopyridine via Halogen Dance and Its Successive One-Pot Disubstitutions

Xin-Fang Duan*a, Xiang-Hong Lia, Fu-You Lib, Chun-Hui Huangb
a Department of Chemistry, Beijing Normal University, Beijing, 100875, P. R. China
Fax: +86(010)62206640; e-Mail: xinfangduan@vip.163.com;
b Institute of Advanced Materials, Fudan University, Shanghai, 200433, P. R. China
Further Information

Publication History

Received 15 March 2004
Publication Date:
29 September 2004 (online)

Abstract

As a key building block for 2,4-disubstituted pyridines, 2-bromo-4-iodopyridine was synthesized conveniently from 2-bromopyridine using LDA and I2 via ‘halogen dance’. 2-Bromo-4-iodopyridine was then converted to other 2,4-diaryl pyridines and 4-aryl-2,2′-bipyridines in one-pot reactions.