Synthesis 2004(15): 2485-2492  
DOI: 10.1055/s-2004-831250
© Georg Thieme Verlag Stuttgart · New York

TFFH as an Excellent Reagent for Acylation of Alcohols, Thiols and Dithiocarbamates

Michael Pittelkowa, Fadhil S. Kamounahb, Ulrik Boasa, Brian Pedersena, Jørn B. Christensen*a
a Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark
Fax: +4535322012; e-Mail:;
b Department of Lifescience and Chemistry, Roskilde University, Universitetsvej 1, Postal Box 260, 4000 Roskilde, Denmark
Further Information

Publication History

Received 17 May 2004
Publication Date:
29 September 2004 (online)


A convenient and easy procedure to synthesize esters and thioesters from the corresponding carboxylic acid using TFFH as the coupling reagent is described. The preparation of N-acyl-dithiocarbamates from carboxylic acids and 1,3-thiazolidine-2-thione with TFFH as the coupling reagent is also described.