1-Isocyano-2-dimethylamino-alkenes: Versatile Reagents in Diversity-Oriented Organic Synthesis

Abstract

1-Isocyano-2-dimethylamino-alkenes are versatile and multifunctional reagents in organic synthesis. Two useful protocols are given for multicomponent reactions (MCRs) for the assembly of a 6-oxo-1,4,5,6-tetrahydropyrazine-2-carboxylic acid methyl ester derivative­ and a highly substituted thiazole. The procedures, in a modified set-up, are useful for array synthesis.

isocyanide - multicomponent reaction - heterocycle synthesis - thiazole

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