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DOI: 10.1055/s-2004-831202
Traceless Solid Phase Synthesis with Polystyrene-Bound Tellurium and in Comparison with Polystyrene-Bound Selenium
Publication History
Publication Date:
25 August 2004 (online)

Abstract
A novel traceless linking strategy by use of polystyrene-bound tellurium is described. The application of the tellurium linker is demonstrated by the solid phase synthesis of a small library of single alkyl aryl ethers containing two points of diversity. Polystyrene-bound tellurium and polystyrene-bound selenium are compared by their cleavage performance under radical conditions (homolysis) at different temperatures. In addition, polystyrene- bound substrates were analysed by the use of high-resolution magic angle spinning (HR-MAS) NMR spectroscopy.
Key words
combinatorial chemistry - solid phase synthesis - traceless linker - polystyrene-bound chalcogenes - HR-MAS NMR spectroscopy
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