Abstract
New amphiphilic nucleosides 3 , 5 , 7 , 9 and nucleobases 12 , 14 , with lipophilic alkynyl substituents attached to the N-heterocyclic ring were obtained
in a straightforward manner by Sonogashira coupling of 5-iodouridine, 8-bromoadenosine
and protected 8-bromoguanosine or related halonucleobases. In most cases protective
groups were unnecessary.
Key words
nucleosides - nucleobases - cross-coupling - amphiphile - alkynes
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Full details have been deposited with the Cambridge Crystallographic Data Centre as
supplementary publication no. CCDC 228985. Copies of the data can be obtained free
of charge on application to CCDC, 12 Union Road, Cambridge, CB2 1EZ, UK.
