Highly Efficient Double-Activation Catalysts for the Synthesis of Ketone Cyanohydrins

Fu-Xue Chen; Xiaohua Liu; Bo Qin; Hui Zhou; Xiaoming Feng; Guolin Zhang

doi:10.1055/s-2004-831167

PAPER

Highly Efficient Double-Activation Catalysts for the Synthesis of Ketone Cyanohydrins

Fu-Xue Chen^a, Xiaohua Liu^a, Bo Qin^a, Hui Zhou^a, Xiaoming Feng*^a, Guolin Zhang^b
^a Key Laboratory of Green Chemistry & Technology (Sichuan University), Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China
Fax: +86(28)85418249; e-Mail: xmfeng@scu.edu.cn;
^b Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, P. R. China

Abstract

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Abstract

Tertiary cyanohydrin trimethylsilyl ethers were synthesized in excellent chemical yields by using salen-Al complex (0.25 mol%) and N-oxide (0.5 mol%) without solvent at ambient temperature. The relationship between the ligand structure and catalyst efficiency is discussed. Preliminary mechanistic studies were carried out, and transition states were proposed accounting for the action of the double-activation catalysts.

Key words

addition reactions - aluminum - ketones - Schiff bases - nitriles

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References

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