Enantioselective Henry Reaction Catalyzed by Salen-Cobalt Complexes

Abstract

The enantioselective Henry reaction catalyzed by the optically active salen-cobalt complexes, proceeded to afford β-hydroxynitroalkanes­ in good-to-high yields with high enantio­selectivity.

Key words

aldehyde - asymmetric catalysis - salen-cobalt complexes - direct nitroaldol reaction - β-hydroxynitroalkanes

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18

In case of contamination with the cobalt-salen complex after the purification by the column chromatography, the pure product could be obtained as follows: To the CH₂Cl₂ solution of the contaminated product (ca. 0.5 mmol), silver hexafluoroantimonate (34.3 mg, 0.1 mmol) was added at -78 °C. After stirring for 30 min, the mixture was purified by a short column chromatography to afford the pure product.